Publications

For full list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=jonathan+c+kagan

2024

2023

Structural insights into cytokine cleavage by inflammatory caspase-4. Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC.Nature. 2023 Dec;624(7991):451-459. doi: 10.1038/s41586-023-06751-9. Epub 2023 Nov 22.PMID: 37993712

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis. Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J.Immunity. 2023 Nov 14;56(11):2523-2541.e8. doi: 10.1016/j.immuni.2023.10.004. Epub 2023 Nov 3.PMID: 37924812

Inflammasomes as regulators of non-infectious disease. Okin D, Kagan JC.Semin Immunol. 2023 Sep;69:101815. doi: 10.1016/j.smim.2023.101815. Epub 2023 Jul 26.PMID: 37506489

Molecular mechanisms of gasdermin D pore-forming activity. Pascal Devant, Jonathan C Kagan, Nat Immunol. 2023 Jul;24(7):1064-1075. doi: 10.1038/s41590-023-01526-w. Epub 2023 Jun 5. PMID: 37277654

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation. Du G, Healy LB, David L, Walker C, Fontana P, Dong Y, Devant P, Puthenveetil R, Ficarro SB, Banerjee A, Kagan JC, Lieberman J, Wu H.bioRxiv. 2023 Mar 7:2023.03.07.531538. doi: 10.1101/2023.03.07.531538. Preprint.PMID: 36945424

Infection infidelities drive innate immunity. Jonathan C Kagan, Science. 2023 Jan 27;379(6630):333-335. doi: 10.1126/science.ade9733. Epub 2023 Jan 26. PMID: 36701444

Excess lipids on endosomes dictates NLRP3 localization and inflammasome activation. Jonathan C Kagan, Nat Immunol. 2023 Jan;24(1):3-4. doi: 10.1038/s41590-022-01364-2. PMID: 36596890

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases. Kenta Mosallanejad, Stephanie N Kennedy, Kristin M Bahleda, Kailey M Slavik, Wen Zhou, Apurva A Govande, Dustin C Hancks, Philip J Kranzusch, Jonathan C Kagan, Sci Immunol. 2023 Jan 20;8(79):eabp9765. doi: 10.1126/sciimmunol.abp9765. Epub 2023 Jan 20. PMID: 36662885

Gasdermin D pore-forming activity is redox-sensitive. Pascal Devant, Elvira Boršić, Elsy M Ngwa, Haopeng Xiao, Edward T Chouchani, Jay R Thiagarajah, Iva Hafner-Bratkovič, Charles L Evavold, Jonathan C Kagan, Cell Rep. 2023 Jan 31;42(1):112008. doi: 10.1016/j.celrep.2023.112008. Epub 2023 Jan 19. PMID: 36662620

2022

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Jonathan C Kagan 1, Craig R Roy, Nat Cell Biol. 2002 Dec;4(12):945-54. doi: 10.1038/ncb883. PMID: 12447391

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family. Charles L Evavold, Jonathan C Kagan, Front Cell Dev Biol. 2022 Jun 27;10:910983. doi: 10.3389/fcell.2022.910983. eCollection 2022. PMID: 35832789

Gasdermin Pore Forming Activities that Promote Inflammation from Living and Dead Cells. Anh Cao, Jonathan C Kagan, J Mol Biol. 2022 Feb 28;434(4):167427. doi: 10.1016/j.jmb.2021.167427. Epub 2021 Dec 29. PMID: 34973239

Lipopolysaccharide detection by the innate immune system may be an uncommon defense strategy used in nature. Anna E Gauthier, Randi D Rotjan, Jonathan C Kagan, Open Biol. 2022 Oct;12(10):220146. doi: 10.1098/rsob.220146. Epub 2022 Oct 5. PMID: 36196535

NLRP3 inflammasomes that induce antitumor immunity. Dania Zhivaki, Jonathan C Kagan, Trends Immunol. 2021 Jul;42(7):575-589. doi: 10.1016/j.it.2021.05.001. Epub 2021 May 22. PMID: 34034975

Innate immune detection of lipid oxidation as a threat assessment strategy. Dania Zhivaki, Jonathan C Kagan, Nat Rev Immunol. 2022 May;22(5):322-330. doi: 10.1038/s41577-021-00618-8. Epub 2021 Sep 21. PMID: 34548649

Control of innate immunity by the cGAS-STING pathway. Kenta Mosallanejad, Jonathan C Kagan, Immunol Cell Biol. 2022 Jul;100(6):409-423. doi: 10.1111/imcb.12555. Epub 2022 May 25. PMID: 35485309

2021

Cytosolic detection of phagosomal bacteria-Mechanisms underlying PAMP exodus from the phagosome into the cytosol. Stephanie A Ragland, Jonathan C Kagan, Mol Microbiol. 2021 Dec;116(6):1420-1432. doi: 10.1111/mmi.14841. Epub 2021 Nov 22. PMID: 34738270

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme. Pascal Devant, Anh Cao, Jonathan C Kagan, Sci Immunol. 2021 Aug 10;6(62):eabh3567. doi: 10.1126/sciimmunol.abh3567. PMID: 34734155

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Charles L Evavold, Iva Hafner-Bratkovič, Pascal Devant, Jasmin M D’Andrea, Elsy M Ngwa, Elvira Boršić, John G Doench, Martin W LaFleur, Arlene H Sharpe, Jay R Thiagarajah, Jonathan C Kagan, Cell. 2021 Aug 19;184(17):4495-4511.e19. doi: 10.1016/j.cell.2021.06.028. Epub 2021 Jul 21. PMID: 34289345

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Megan H Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A Garlick, Jonathan C Kagan, Immunity. 2021 Jul 13;54(7):1447-1462.e5. doi: 10.1016/j.immuni.2021.04.012. Epub 2021 May 11. PMID: 33979579

Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns. Michael J Ernandes, Jonathan C Kagan 2021, Apr 13;12(2):e00584-21. doi: 10.1128/mBio.00584-21. PMID: 33849978

Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Anna E Gauthier, Courtney E Chandler, Valentina Poli, Francesca M Gardner, Aranteiti Tekiau, Richard Smith, Kevin S Bonham, Erik E Cordes, Timothy M Shank, Ivan Zanoni, David R Goodlett, Steven J Biller, Robert K Ernst, Randi D Rotjan, Jonathan C Kagan, Sci Immunol. 2021 Mar 12;6(57):eabe0531. doi: 10.1126/sciimmunol.abe0531. PMID: 33712473

2020

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity. Zhivaki D, Borriello F, Chow OA, Doran B, Fleming I, Theisen DJ, Pallis P, Shalek AK, Sokol CL, Zanoni I, Kagan JC. Cell Rep. 2020 Nov 17; 33(7):108381. PMID: 33207188

Mitochondrial Reactive Oxygen Species Participate in Signaling Triggered by Heme in Macrophages and upon Hemolysis. Prestes EB, Alves LS, Rodrigues DAS, Dutra FF, Fernandez PL, Paiva CN, Kagan JC, Bozza MT. J Immunol. 2020 Nov 15; 205(10):2795-2805. PMID: 33037139

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. Science. 2020 Sep 18; 369(6510):eaas8995. PMID: 32943500

Toll-like Receptors and the Control of Immunity. Fitzgerald KA, Kagan JC. Cell. 2020 Mar 19; 180(6):1044-1066. PMID: 32164908.

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells. Stanifer ML, Mukenhirn M, Muenchau S, Pervolaraki K, Kanaya T, Albrecht D, Odendall C, Hielscher T, Haucke V, Kagan JC, Bartfeld S, Ohno H, Boulant S. Nat Microbiol. 2020 Jan; 5(1):181-191. PMID: 31686029

Lipids that directly regulate innate immune signal transduction. Barnett KC, Kagan JC. Innate Immun. 2020 Jan; 26(1):4-14. PMID: 31180799

2019

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System. Evavold CL, Kagan JC. Immunity. 2019 Oct 15;51(4):609-624. PMID: 31473100

Gasdermin D activity in inflammation and host defense. Lieberman J, Wu H, Kagan JC. Sci Immunol. 2019 Sep 6;4(39):eaav1447. PMID: 31492708

Patterns, dynamics and consequences of microplastic ingestion by the temperate coral, Astrangia poculata. Rotjan RD, Sharp KH, Gauthier AE, Yelton R, Lopez EMB, Carilli J, Kagan JC, Urban-Rich J. Proc Biol Sci. 2019 Jun 26;286(1905):20190726. PMID: 31238843

Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World. Odendall C, Kagan JC. Microbiol Spectr. 2019 May ;7(3):10.1128/microbiolspec.BAI-0011-2019. PMID: 31152521

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation. de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Cell Rep. 2019 Apr 23; 27(4):1165-1175.e5. PMID: 31018131

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Tan Y, Kagan JC. Cell. 2019 Apr 4; 177(2):384-398.e11. PMID: 30853218

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Cell. 2019 Mar 7; 176(6):1432-1446.e11. PMID: 30827685

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores. Evavold CL, Kagan JC. Immunity. 2019 Jan 15; 50(1):15-17. PMID: 30650374

For full list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=jonathan+c+kagan