Two sets of innate immune proteins detect pathogens. Pattern recognition receptors (PRRs) bind microbial products, whereas guard proteins detect virulence factor activities by the surveillance of homeostatic processes within cells. The Kagan lab studies several aspects of PRR and guard protein biology, with particular focus on Toll-like Receptors, RIG-I like Receptors, cGAS-STING and the PRRs and guards that stimulate inflammasomes. These proteins control most (perhaps all) aspects of inflammation and immunity to infection, tissue injury and cancer.
Kagan Lab 
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